Selective IgA deficiency (SIgAD) and common variable immunodeficiency (CVID)
نویسندگان
چکیده
منابع مشابه
Progression of selective IgA deficiency to common variable immunodeficiency.
Selective IgA deficiency (IgAD) is the most common primary immunodeficiency in Caucasians. Although it is often asymptomatic, selected patients show an increased frequency of infections, allergies and autoimmune manifestations. Common variable immunodeficiency (CVID) is a primary antibody deficiency disease that shares many clinical features with IgAD. A common genetic basis for IgAD and CVID h...
متن کاملRole of apoptosis in common variable immunodeficiency and selective immunoglobulin A deficiency.
Common variable immunodeficiency (CVID) and selective IgA deficiency (SIgAD) are the most common primary immunodeficiencies in human. Both diseases share clinical manifestation and molecular defects. Increased apoptosis may be one of the mechanisms involved in the pathogenesis of CVID and SIgAD. Elevated apoptosis in this disorder leads to defective long-term survival of B-cells, reduced antibo...
متن کاملAutoimmunity and infection in common variable immunodeficiency (CVID).
Common variable immunodeficiency (CVID) is a heterogeneous group of diseases, characterized by primary hypogammaglobulinemia. B and T cell abnormalities have been described in CVID. Typical clinical features of CVID are recurrent airway infections; lymphoproliferative, autoinflammatory, or neoplastic disorders; and autoimmune diseases among which autoimmune thrombocytopenia (ITP) is the most co...
متن کاملClinical and Immunological Spectrum of Common Variable Immunodeficiency (CVID).
We have analysed data from 150 patients initially classified as having CVID. About 10% had laboratory abnormalities suggesting known single gene disorders (eg: hyper-IgM syndrome), and in a few a genetic defect has been confirmed. We have attempted to sub-classify the remaining patients by analysis of their circulating lymphocytes. B lymphocyte markers have been used to estimate the numbers of ...
متن کاملclinical and immunological spectrum of common variable immunodeficiency (cvid)
we have analysed data from 150 patients initially classified as having cvid. about 10% had laboratory abnormalities suggesting known single gene disorders (eg: hyper-igm syndrome), and in a few a genetic defect has been confirmed. we have attempted to sub-classify the remaining patients by analysis of their circulating lymphocytes. b lymphocyte markers have been used to estimate the numbers of ...
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ژورنال
عنوان ژورنال: Clinical & Experimental Immunology
سال: 2000
ISSN: 0009-9104
DOI: 10.1046/j.1365-2249.2000.01131.x